报告题目：Electrophilic Hypervalent Trifluoromethylthio-Iodine(III) Reagent
报告时间：2024年9月23日上午11:00-12:00
报告地点：16幢一楼路演厅
报 告 人：张弛

邀 请 人：彭勃

报告人简介：
张弛, Ph.D.

1986-1990, B.S. in Chemistry, Lanzhou University, China

1993-1996, M.Sc. in Chemistry, Lanzhou University, China

1996-2001, Ph.D in Chemistry, The University of Hong Kong, China

2001-2003, Postdoctoral Fellow. Stanford University

2003- now, Professor in Chemistry, Nankai University

New Century Excellent Talents in University (2007).

报告简介：
Hypervalent iodine(III) reagents are important functional group-transfer reagents and have been widely used in synthetic chemistry, because of their fertile reactivities, excellent chemoselectivities, mild reaction conditions, and environmental benign characteristics. Therefore, the development of new hypervalent iodine(III) reagents and new reactions promoted by hypervalent iodine(III) reagents is of great significance. Trifluoromethylthio group (–SCF3) is an important fluorinated group, which shows promise for the development of drugs and agrochemicals. We report the design and synthesis of the first N-acetylbenziodazolone-based hypervalent trifluoromethylthio-iodine(III) reagent (TFTI) whose structure and properties have been carefully investigated. We also report the reactivities of TFTI, including: (1) electrophilic trifluoromethylthiolation of nucleophiles; (2) dehydroxy-trifluoromethylthiolation of alcohols in combination with N-heterocyclic carbene; (3) direct trifluoromethylthiolation of terminal alkynes.

代表性论文：

1. J. Ren, F.-H. Du, M.-C. Jia, Z.-N. Hu, Z. Chen, and C. Zhang.^*Angew. Chem. Int. Ed., 2021, 60, 24171–24178.

2. Y.-X. Cheng,^‡ X.-G. Yang,^‡ F.-H. Du^‡, and C. Zhang.^*Green Chem., 2024, 26, 5914-5920.

3. M.-Q. Huang, J.-J. Li, and C. Zhang.^*Green Chem., 2023, 25, 9187-9193.

4. J. Ren,^‡ M.-C. Jia, ^‡ F.-H. Du, and C. Zhang.^*Chin. Chem. Lett., 2022, 23, 4834–4837.

5. X.-G. Yang, K. Zheng, and C. Zhang.^*Org. Lett. 2020, 22, 2026-2031.