报告题目：Carbon-Skeleton Rearrangement via C-C s Bond Activation
报告时间：2023年11月25日16:30-17:30
报告地点：16幢921报告厅
报告人：曾伟
邀请人：邓卫平

报告人简介：
曾伟，教授，博士生导师。1994年本科毕业于四川大学化学系。1994‒1997年在中国工程物理研究院工作。1997‒2003年在四川大学化学化工学院获得硕士和博士学位。2004‒2005年在香港大学从事研究助理工作。2005‒2008年先后在North Carolina State Univ., (Prof. C. Melander)和The State Univ. of New York at Buffalo (Prof. S. Chemler) 从事博士后研究工作。2008年‒至今在华南理工大学从事教学科研工作，目前任广东省功能分子工程重点实验室副主任和第六届Chin. Chem. Lett.编委。自独立开展研究工作以来，先后在Angew. Chem. Int. Ed., Nat. Commun., Chem. Sci., ACS Catal.等化学类国际主流期刊发表SCI论文70余篇。

报告简介：
The Beckmann rearrangement, semi-pinacol rearrangement, Smiles rearrangement, Wolff rearrangement, and others have been successively developed to allow for diversified group migration via parallel moving pattern. Meanwhile, the Cope and Claisen rearrangement and Witting rearrangement represent another type of cyclic transition state-based [3,3′]- and [2,3′]-sigmatropic shift, one of the most important features of these rearrangements involves synergetic C–X bond (X = C, O, N, etc.) formation and double-bond migration at pericyclic reaction-sites. To date, these classical group migratory and sigmatropic rearrangements have shown extremely potential in strategic synthesis of natural products, pharmaceuticals, and material molecules. However, it is surprising that 1,2- and 1,3-sigmatropic rearrangements, which only involve two different reaction-sites, have remained unexplored, this method will probably establish a new platform to enable unprecedented in-situ group-inversion rearrangement. Encouraged by our previous C–H, C–C, and C–S bond functionalization strategies, herein we represented a novel and feasible carbon-skeleton rearrangement model through in-situ group inversion.

代表性论文：

1.  Nat. Commun. 2023, 14, 1862.

2.  Nat. Commun. 2021, 12, 3304.

3.  ACS Catal. 2020, 10, 8402.

4.  Chem. Sci. 2018, 9, 985.

5.  Angew. Chem. Int. Ed. 2016, 55, 11897.