报告题目：Reductive Dimetalation of Alkynes
报告时间：10月19日上午10:00-11:00
报告地点：7幢301报告厅
报告人：Hideki Yorimitsu
邀请人：彭勃

报告简介：
Reductive metalation of π bonds is a well-known process that typically leads to the formation of protonated products such as trans-alkenes via carbanions. However, the application of such reactions for nonprotonative transformations has been restricted due to the inherent instability of radical anion intermediates. In this talk, I will discuss recent developments in the generation of carbanions by reductive metalation of alkynes in the presence of reduction-resistant electrophiles.

  The use of trialkoxyboranes as reduction-resistant electrophiles is firstly discussed. These compounds effectively capture carbanions through their available vacant p orbitals, realizing reductive syn-diboration of alkynes. Subsequently, reductive anti-dimagnesiation and -dialumination of alkynes using Mg- and Al-based reduction-resistant electrophiles will be discussed. Finally, the reductive borylmetalation of alkynes using flow microreactors will be disclosed.This microreactor-based strategy offers enhanced control and efficiency in the regio- and stereoselective synthesis of multi-substituted alkenes.

报告人简介：
Hideki Yorimitsu教授，1997年和2002年先后于日本京都大学获学士学位和博士学位；2002-2003年在东京大学从事博士后研究；2003年至今分别在京都大学材料化学学院和化学学院先后担任助理教授、副教授、正教授。他在惰性键（C-H、C-O、C-S）的官能团化以及硫、硫砜转化领域取了杰出的成就。先后获得日本化学会青年化学家奖，日本JSPS研究奖等多个奖项。兼任ASC Advances和SYNTHESIS杂志副主编。在J.    Am. Chem. Soc., Angew. Chem. Int. Ed. 等国际知名学术刊物上发表论文300余篇，发表和出版相关专著50余本。主要研究方向包括：基于有机金属物种新反应的开发，过渡金属催化以及功能分子中杂原子的引入。

代表性论文：

1）  Wang, S.; Larrosa, I.; Yorimitsu, H.; Perry, G. J.. Angew. Chem. Int. Ed.2023, 62, e2022183713.

2）  Takahashi, F.; Kurogi, T.; Yorimitsu, H. Nat. Synth. 2023, 2, 162.

3）  Okamoto, K.; Hori, M.; Yangi, T.; Murakami, K.; Nogi, K.; Yorimitsu, H. Angew. Chem. Int. Ed.2018, 57, 14230.

4）  Saito, H.; Nogi, K.; Yorimitsu, H. Angew. Chem. Int. Ed.2018, 57, 11030.

5）  Hori, M.; Guo, J.-D.; Yangi, T.; Nogi, K.; Sasamori, T.; Yorimitsu, H. Angew. Chem. Int. Ed.2018, 57, 4663